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Specific genetic factors may lead to negative response to AREDS formulation
FLORENCE, Italy — High-dose zinc, as in the AREDS and AREDS2 formulations, may be harmful in patients with high complement factor H and low age-related maculopathy susceptibility 2 risk alleles, according to one speaker. “There is considerable evidence that response to AREDS supplements is influenced by genetic risk,” Carl C. Awh, MD, said at the FLOREtina meeting.