A cluster of post-intravitreal injection inflammatory reaction cases was associated in a study with silicone oil droplets released by Saldanha Rodrigues syringes.
The study was designed after six of 33 eyes receiving aflibercept intravitreal injection in one hospital in Brazil between May and August 2016 developed symptoms and signs of inflammation, primarily anterior uveitis and vitritis. The medical records were analyzed to identify possible contributing factors and biophysical tests were performed to determine if specific substances in the syringes might have altered the aggregation states
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