HONOLULU — Safety and tolerability objectives were met in a phase 1/2 first-in-human study of topical SF0166, a topical ophthalmic solution candidate for treatment of diabetic macular edema, a speaker said here.
“Safety and tolerability were excellent, and there was no evidence of corneal toxicity,” D. Scott Edwards, PhD, said at the Association for Research in Vision and Ophthalmology meeting.
Edwards presented data from a randomized, double-masked, multicenter study of 40 patients with DME randomized 1:1 in two arms to receive 1.25 mg or 2.5 mg SF0166 (SciFluor) twice a (Read more...)
Author: Healio ophthalmology
VIDEO: OCTA can lead to better understanding of diabetic retinopathy
HONOLULU — At the Association for Research in Vision and Ophthalmology meeting here, Javier Zarranz-Ventura, MD, PhD, FEBO, discusses a large-scale prospective study evaluating the use of OCT angiography in assessing diabetic retinopathy progression.
Targeted laser photocoagulation treats select cases of diabetic retinopathy
HONOLULU — Targeted retinal photocoagulation may be used to treat severe nonproliferative diabetic retinopathy as well as some cases of proliferative diabetic retinopathy, according to a poster presented here.
Pallavi Singh, MD, of Dr. Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, and colleagues undertook a nonrandomized, prospective, interventional study of 30 treatment-naive eyes with NPDR or PDR without high-risk characteristics (HRC) treated with targeted retinal photocoagulation over capillary nonperfusion areas.
Areas of treatment were identified with Optos
VIDEO: Dexamethasone inserts show success in eyes with DME
HONOLULU — Repeated dexamethasone inserts are a safe option for diabetic macular edema, especially for treatment-naive eyes, according to an International Retina Group study presented by Catharina Busch, MD, at the Association for Research in Vision and Ophthalmology meeting here.
VIDEO: Study finds NovaTears can increase tear film thickness
HONOLULU — At the Association for Research in Vision and Ophthalmology meeting here, Gerhard Garhöfer, MD, discusses a study investigating the effect of NovaTears (Novaliq) on tear film thickness in dry eye patients.
EHRs need overhaul to limit time spent on them
NEW ORLEANS — Electronic health records need to meet clinical needs, not administrative ones, to prevent physicians from spending too much on the technology, according to a presenter at the American College of Physicians Internal Medicine Meeting.
“It’s particularly worrisome that there’s a great deal of dissatisfaction among physicians regarding EHRs, and how much time they spend on them,” Elmer V. Bernstam, MD, associate dean for research at the University of Texas Health Science Center at Houston, told Healio Family Medicine.
“There are many reasons for
VIDEO: ROCKET 2 demonstrates comparable efficacy of Rhopressa, timolol
HONOLULU — The ROCKET 2 trial found once-daily treatment with Aerie Pharmaceuticals’ Rhopressa (netarsudil ophthalmic solution 0.02%) to be comparable with twice-daily treatment with timolol maleate 0.05% while maintaining a similar side effect profile, Janet B. Serle, MD, said at the Association for Research in Vision and Ophthalmology meeting here.
Deep learning methods extend physician expertise
HONOLULU — Deep learning methods have great potential to extend the expertise of physicians who diagnose and treat diabetic retinopathy, Rory Sayres, PhD, a researcher for Google, said at the Association for Research in Vision and Ophthalmology meeting here.
Sayres and colleagues looked at the impact on accuracy, speed and confidence of physicians when algorithms developed from machine learning methods were applied to assist in grading retinal fundus images for diabetic retinopathy.
Using more than 1,800 images from EyePACS, Sayres and colleagues recruited nine ophthalmologists to read
VIDEO: Brolucizumab treatment frequency predicted by first dosing interval
HONOLULU — The recent HAWK and HARRIER trials of Novartis’ brolucizumab for the treatment of neovascular age-related macular degeneration has helped researchers predict which patients will need an 8-week dosing regimen or a 12-week regimen with an almost 90% predictability rate, Pravin Dugel, MD, said at the Association for Research in Vision and Ophthalmology meeting here.
Scleral implants may improve near visual acuity in patients with presbyopia
HONOLULU — A subset of patients treated for presbyopia with scleral implants experienced a clinically significant improvement in near visual acuity, according to a poster presented at the Association for Research in Vision and Ophthalmology meeting here.
“Preliminary data indicates that VisAbility micro-insert system (Refocus Group) may significantly improve near vision,” Frank A. Bucci Jr., MD, wrote in the poster.
Researchers evaluated visual acuity of a subsample of 20 patients from two centers in a multicenter FDA trial who received scleral implants and were followed for
Aerie launches Rhopressa in US
Aerie Pharmaceuticals announced the launch of Rhopressa in the United States for the treatment of patients with open-angle glaucoma or ocular hypertension.Rhopressa (netarsudil ophthalmic solution 0.02%) is now available nationally and regionally throu…
Primary IOL implantation an option for managing pediatric cataract
HONOLULU — Primary IOL implantation to treat and manage cataract in children younger than 1 year of age should be considered, according to Emi Sanders and William F. Astle, MD, FRCSC, who presented a poster on the topic at the Association for Research in Vision and Ophthalmology meeting here.
“Bilateral and unilateral cataracts in infants under 12 months of age require early treatment in order to prevent permanent loss of vision and amblyopia,” the authors wrote.
In the retrospective chart review, 54 eyes of 39 patients who underwent primary IOL (Read more...)
Woman presents with bilateral rapidly progressive blurry vision and eye pain
A 59-year-old woman presented to an outside ophthalmologist with 1 week of blurry vision, headache, eye pain and tearing in both eyes. She was found to have anterior chamber inflammation with elevated IOP in the low 30s bilaterally. The ophthalmologist…
What is the most effective strategy for protecting your intellectual property?
Click here to view the Cover Story for this Point/Counter.The short answer would be you need to have a mutual nondisclosure agreement (NDA) that goes between you and anyone you may discuss your ideas with. The mutual portion of this is important to und…
The three Ps to facilitate the premium channel conversion
The three Ps, no matter the industry or business discussed, always come down to the three same principles: people, process, product. There are many variations of the three Ps, and occasionally there is a fourth P known as performance. The core ideas ar…
Psychometric exam valuable in evaluation of dry eye patients
There are several reasons why it is advantageous to use a psychometric exam to evaluate dry eyes: It shortens the visit, as you already know the patient’s chief complaint(s) and the severity level. If the patient checks off even one dry eye/ocular surface complaint, it allows your technicians to proceed with dry eye tests before you enter the exam lane. If you order them after your history and slit lamp exam with proparacaine/fluorescein, it may be too late to order some of them, such as the tear osmolarity test. Ordering (Read more...)
Ocular surface squamous neoplasia seen in congenital ichthyosis
Ocular surface squamous neoplasia, or OSSN, is seen often as an abnormal growth in the ocular surface predominantly near the limbus. Immunosuppression and ultraviolet light exposure are known high risk factors for developing OSSN. DNA repair defects su…
Preoperative strategies manage astigmatism before cataract surgery
Determining if astigmatism is regular or irregular before cataract surgery can greatly improve postoperative outcomes and patient expectations.
A patient with regular astigmatism can expect to undergo a routine cataract surgery with a toric IOL placement, but if a patient has greater than 1.5 D of astigmatism or irregular astigmatism, then additional preoperative steps are needed to ensure positive outcomes, OSN Cataract Surgery Board Member Audrey Talley Rostov, MD, said.
“In regard to determining the axis and amount of astigmatism, there are many different ways of doing this. I
Mazzo explains challenge of formulating one team with one successful global message
James “Jim” Mazzo, global president ophthalmic devices for Carl Zeiss Meditec, graciously agreed to sit for my first “Challenges in Ophthalmology” interview. I have been fortunate to call Jim a dear friend for many years, and I also have a deep respect for his work ethic and opinion on all matters ophthalmology.
After combing through Jim’s CV, it is tough not to notice that he has run several multinational corporations and has lived abroad in several countries. I asked Jim about his time overseas, and it was not long before (Read more...)
Less is more with glaucoma surgery
The glaucoma surgery procedure profile has expanded, with many choices for the surgeon to utilize to assist in the management of sight-threatening glaucoma, while decreasing the potential iatrogenic and procedure-specific complications that can be asso…