In patients with wet age-related macular degeneration
(AMD), all regimens of aflibercept (VEGF Trap-
Eye, Regeneron), including aflibercept dosed every
2 months, achieved the primary endpoint compared
with ranibizumab (Lucentis, Genentech) dosed every
…
Author: Retina Today
Ranibizumab Improved Visual Outcomes in DME
Patients with DME achieved better long-term visual
outcomes when treated with ranibizumab (Lucentis,
Genentech) and focal/grid laser combination therapy
than with ranibizumab or laser alone, according to the
results of the phase 2 READ-2 study publishe…
Carl Zeiss Introduces Multispot Photocoagulation Laser
Carl Zeiss Meditec, Inc. (Dublin, CA), introduced the
Visulas 532s Vite photocoagulator at the AAO in Chicago.
The device recently received marketing clearance from
the FDA. According to the company, the Visulas 532s Vite
photocoagulator features varia…
FAME: 24-month Readout Shows Steady Improvement
Vision continued to significantly improve at 2 years with
the fluocinolone acetonide intravitreal insert (Iluvien,
Alimera Sciences), according to Baruch D. Kuppermann,
MD, PhD, who presented the 24-month readout of the
FAME trial at the American Acade…
Accumulated Doses of Irradiation to the Lens May be Cataractogenic
Irradiation toxic effects of intra-arterial chemotherapy
may be cataractogenic and possibly carcinogenic, especially
in irradiation-sensitive patients with retinoblastoma,
according to a study published in the Archives of
Ophthalmology.1
The prospectiv…
EyeGate to Develop Corticosteroid Solution for Retinal Disorders
EyeGate Pharma (Waltham, MA) announced that it
has received four federal grants totaling nearly $1 million
for programs that focus on the continued clinical development
of EGP-437, a corticosteroid solution administered by the EyeGate II delivery syste…
Microplasmin Meets Primary Endpoint in Two Phase 3 Trials for Vitreomacular Adhesion
A single injection of microplasmin (ThromboGenics
NV) for the nonsurgical treatment of vitreomacular adhesion
(VMA) performed well in two phase 3 trials, referred
to as MIVI-TRUST, according to presenters at the ASRS.
Both trials were multicenter, rand…
Ozurdex Reduced DME in Vitrectomized Eyes
The Ozurdex dexamethasone intravitreal implant
(Allergan, Inc.) effectively reduced DME and improved
visual acuity in vitrectomized eyes, according to data presented
by Leonard Feiner, MD, at the ASRS meeting.1
In a 6-month, prospective, multicenter, o…
RXi Pharmaceuticals and EyeGate Pharma Partner For Noninvasive Ocular Delivery of RNAi Therapeutics
RXi Pharmaceuticals Corporation (Worcester, MA) and
EyeGate Pharma (Waltham, MA) have announced a partnership
to deliver ocular RNAi therapeutics to treat retinal
disorders. Each party will contribute technology, expertise,
and resources to the collabo…
Vision Improved as Early as 1 Week With Iluvien
At the American Society of Retina Specialists (ASRS)
meeting in Vancouver, P. Andrew Pearson, MD, provided
an update on the phase 3 clinical trials, collectively
known as the FAME study, involving the Iluvien (Alimera
Sciences, Inc.) intravitreal inser…
Ozurdex Approved as Treatment for Noninfectious Uveitis of the Posterior Segment
The US Food and Drug Administration (FDA) has
approved Ozurdex (dexamethasone intravitreal implant
0.7 mg; Allergan, Inc.) for the treatment of noninfectious
uveitis affecting the posterior segment, according to a
company news release.
Ozurdex is a bio…
FDA Awards Grant for Phase 2 Trial to Deliver Sustainable LCA Treatment
Applied Genetic Technologies Corporation
(Gainesville, FL) announced that it has received a
$1 million grant from the FDA through its Orphan Drugs
Program to fund a phase 2 human clinical trial evaluating
the safety and efficacy of a treatment for Lebe…
Combined Surgery With the Constellation Vision System Was Safe and Effective in Study
Both 23- and 25-gauge microincisional vitrectomy surgery
(MIVS) with the Constellation Vision System (Alcon
Laboratories Inc., Fort Worth, TX) may be effectively
combined with phacoemulsification without significant
increases in preoperative or postope…
Navilas Effective in Treatment and Management of Patients With DME in Pilot Study
The Navilas laser system (OD-OS Inc., San Francisco,
CA) offers improved visualization, ergonomics, and imaging
over traditional retinal laser therapy, and it helps with
treatment planning and execution, Richard Rosen, MD,
said at meeting of the Europe…
Excessive Weight Gain During Pregnancy Affects Birth Weight
Maternal weight gain during pregnancy influenced the
baby’s birth weight independently of genetic factors,
according to a study in the Lancet.1
David Ludwig, MD, and Janet Currie, PhD, of Children’s
Hospital Boston studied data from 513,501 women a…
Low Levels of Tobacco Smoke Exposure Affect Lungs
A single cigarette produces enough smoke to alter
genes in the lungs, according to a study in the American
Journal of Respiratory and Critical Care Medicine.1 Low
levels of tobacco smoke produce biologic changes in the
small airway epithelium, the site…
Girls Starting Puberty at Younger Age
The proportion of girls who had breast development at
ages 7 and 8 years, particularly among white girls, is greater
than that reported from studies of girls who were born 10
to 30 years earlier, according to a study in Pediatrics.1
The study, conducte…
Spinal Fluid Test Predicted Alzheimer Disease
A spinal fluid test can be 100% accurate in identifying
patients with significant memory loss who are developing
Alzheimer disease, according to a study in the
Archives of Neurology.1
John Trojanowski, MD, PhD, of the University of
Pennsylvania, and co…
Microvascular Decompression Surgery Improved Glucose Control in Patients With Diabetes
A vascular compression of the medulla oblongata is a
factor in some patients with type 2 diabetes, and therefore
microvascular decompression surgery (MVD) may
be an effective treatment for patients with nonobese
type 2 diabetes mellitus, according to a…
CDC Says Obesity Rates Continue to Rise
About one-third of people in nine US states were
obese in 2009. This is a dramatic increase from 2007,
when only three states had obesity rates that high,
according to a recent survey by the Centers for Disease
Control and Prevention (CDC).1 The result…