Sulfur hexafluoride tamponade reduces detachment rate in DMEK

Tamponade with 20% sulfur hexafluoride was associated with a markedly lower rate of graft detachment than 100% air tamponade in Descemet’s membrane endothelial keratoplasty, a study found.Because most graft detachments occur in the early postoperative period after DMEK, there is a need for a longer-lasting tamponade agent to decrease the need for air reinjections. The use of 20% sulfur hexafluoride (SF6) has previously shown a low reinjection rate of 6.6%, but concerns exist about toxicity to the corneal endothelium.