LinkOPH

Purpose:
To describe the outcomes of different treatment approaches for cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART).

Design:
Prospective cohort study, the Longitudinal Study of the Ocular Complications of AIDS.

Participants:
A total of 250 patients with CMV retinitis and a CD4+ T-cell count <100 cells/μl (n = 221) at enrollment or incident retinitis (n = 29) during cohort follow-up.

Methods:
The effects of systemic therapy (vs. intraocular therapy only) on systemic outcomes and the effect of intraocular therapies (ganciclovir implants, intravitreal injections) on ocular outcomes were evaluated.

Main Outcome Measures:
Mortality, CMV dissemination, retinitis (Read more...)

Objective:
To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation.

Design:
Secondary outcome analysis in a prospective, randomized clinical trial.

Participants:
The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with a unilateral congenital cataract.

Intervention:
Infants underwent cataract surgery with or without placement of an IOL.

Main Outcome Measures:
The proportion of patients in whom strabismus developed during the first 12 months of follow-up was calculated using the life-table method (Read more...)