Researchers at MIT have developed an enhanced mRNA vaccine system that can elicit a greater immune response at lower doses. The vaccine technology is so potent that it may be useful for intranasal COVID-19 vaccines. This would have the benefit of localized immunity in the nasal mucus membranes that could kill the SARS-CoV-2 virus before […]
Tag: covid
Enhanced mRNA Vaccine May Work Intranasally.
Researchers at MIT have developed an enhanced mRNA vaccine system that can elicit a greater immune response at lower doses. The vaccine technology is so potent that it may be useful for intranasal COVID-19 vaccines. This would have the benefit of localized immunity in the nasal mucus membranes that could kill the SARS-CoV-2 virus before […]
Micelle Technology Detects Airborne SARS-CoV-2
At the Pacific Northwest National Laboratory, researchers have developed micelle technology that can detect minute amounts of SARS-CoV-2 in the air. This new capability could provide invaluable monitoring systems to detect viral contamination in healthcare facilities and beyond. Micelles are somewhat similar to liposomes in that they are both like (Read more...)
mRNA Therapy Prevents COVID Virus Entering Cells
Scientists at Oregon State University have developed a new treatment for COVID-19. The technology is based on mRNA, which has also been put to good use in COVID-19 vaccines. However, in this instance, the delivered mRNA encodes for human angiotensin-converting enzyme 2 (hACE2), which is the binding site for SARS-CoV-2 on airway cells. The lipid [&h (Read more...)
CRISPR-Cas13 System for Quick and Sensitive SARS-CoV-2 Detection
Scientists at Rice University created a rapid COVID-19 test that is based on the gene editing CRISPR-Cas system. The researchers modified the Cas-13 protein to increase its activity and to light up with fluorescence when it encounters RNA from the virus. The system does not require the expensive lab equipment and technical expertise of PCR, [&helli (Read more...)
DNA Nets Capture Sars-CoV-2 for Detection and Inhibition
A team at the University of Illinois at Urbana-Champaign has developed a DNA net system that can ensnare Sars-CoV-2 and bind to the notorious spike protein. The nets contain aptamers that bind the spike protein and emit an intense fluorescent signal once they’re bound together to the protein. This signal can be easily measured using [… (Read more...)
Microparticle Vaccine Provides Boosters Automatically
Researchers at MIT have created a microparticle vaccine that can provide booster doses automatically. The hollow microparticles resemble a coffee cup with a lid, and are made using poly(lactic-co-glycolic acid), otherwise known as PLGA. The polymer breaks down over time in the body, releasing the contents of the hollow particles. By changing the co (Read more...)
Anti-COVID Nanobubbles Act as Viral Decoys
Researchers at Northwestern University have discovered naturally-occurring extracellular vesicles in the blood that contain the ACE2 protein, which is the cellular target of SARS-CoV-2. The vesicles act as a binding site for viral particles within the body, and prevent them from binding to and infecting cells. Unlike vaccines, therapeutics based on (Read more...)
DNA Aptamers for Rapid COVID-19 Testing: Interview with Steven Goh, CEO of Achiko and Dr. Michael Edel, Inventor of AptameX
Achiko, a company based in Switzerland, has developed AptameX, a saliva-based rapid COVID-19 test. The technology is based on DNA aptamers that are bound to gold nanoparticles. On binding with a viral protein the gold nanoparticles are released, causing a measurable color change. The test takes approximately 15 minutes in total, with the user spend (Read more...)