Single-cell sequencing has shown a lot of promise in identifying genetic differences between cells in a given tissue sample. It is particularly useful for understanding heterogeneity and evolution in resected tumors, and is increasingly used for improving precision medicine approaches. Unfortunately, conventional methods are cost-prohibitive, thus (Read more...)
Tag: Pathology
DNA Computer Can Sense Multiple Antibody Inputs, With Potential for Smart Drug Delivery
Researchers at the University of Eindhoven in the Netherlands have developed a DNA computer that can respond to the presence of specific antibodies and make calculations, with the potential for intelligent drug delivery in the future. DNA computing involves using DNA molecules and other molecular biological components as molecular circuitry, instea (Read more...)
Cheap Ultrasensitive HIV Sensor to Help Screen Virus in Poorer Places
At the Instituto de Microelectrónica de Madrid, researchers have developed a tiny, cheap, portable sensor potentially capable of detecting HIV in people within a week of infection. These days nucleic acid amplification is the clinical standard, but it’s too expensive for many places around the world. Besides preventing early detection, (Read more...)
Adaptive Liquid Lenses and Smartphones Shrink Digital Pathology Into a Tiny Portable Device
At Ohio State University researchers have developed a portable pathology slide scanner that uses a smartphone to image, display, and share the scans. Unlike conventional microscopy, digital pathology devices image the entire slide and therefore provide a much wider field of view. This makes it easier to identify tissues that may be a and indicator (Read more...)
Cheap Method for Printing Lab-on-Chip Devices Promises Diagnostic Revolution
Scientists at Stanford University have developed a new method of manufacturing lab-on-chip devices that cost only pennies to make, which can be used for research and point-of-care diagnostics, particularly in poorer places around the world. The investigators built such devices and showed that they can be used to separate cells from a sample, isolat (Read more...)
New Imaging Technique Provides Quick Tumor Diagnosis During Brain Surgeries
If a tumor is suspected during brain surgery, it takes 30-40 minutes from the time of removing the sample from the patient’s brain to the time of diagnosis. The sample is taken through a rigorous process of tissue sectioning, staining, mounting, and interpretation by pathologists. Researchers from University of Michigan have now developed an (Read more...)
A Breathalyzer to Detect Inflammatory Signs of Influenza Infection
Detecting diseases non-invasively by sampling exhaled breath is a growing field. Previously, we featured Owlstone Medical, who have developed breath sampling devices to store breath samples for later analysis along with an integrated unit for the detection of lung cancer biomarkers. Recent research on breath testing has suggested that viral in (Read more...)
PerkinElmer’s New Vectra Polaris Automated Quantitative Pathology System for Studying Cancer Immunotherapies
PerkinElmer is releasing a new automated quantitative pathology system, the Vectra Polaris. It was developed to help study how cancer immunotherapies are affecting their targets and nearby tissues. The machine is able to detect multiple immunohistochemical stains simultaneously thanks to multispectral imaging using seven colors, allowing for m (Read more...)
Tiny Acoustofluidic Chip Separates Nanoparticles from Liquid Samples to Detect Disease
Scientists at Duke University have developed a way of concentrating nanoparticles inside a small device using only sound waves. This achievement may help introduce portable diagnostics that rely on attaching nanoparticles to biomarkers such as proteins and measuring how many find their targets. There is now a large selection of nanoparticles, (Read more...)
Lens-Free Automated Cell Counting System for Diagnosis of Meningitis
French researchers from Grenoble Alpes University and Aix-Marseille University have developed an automated lens-free microscopy technique for counting and telling apart red and white blood cells withing cerebrospinal fluid. Cerebrospinal fluid, gathered through a spinal tap, should be clear and have few, if any, blood cells within it. Patients with (Read more...)