The p53 Codon 72 Polymorphism (rs1042522) Is Associated with Proliferative Vitreoretinopathy: The Retina 4 Project

Purpose: To compare the distribution of a p53 gene polymorphism among European subjects undergoing primary retinal detachment (RD) surgery in relation to the development of proliferative vitreoretinopathy (PVR). Design: Case-controlled gene association study conducted as a component of the Retina 4 Project (a European multicenter study). Participants and Controls: Five hundred fifty DNA samples, 134 with PVR secondary to primary RD and 416 with RD without PVR. Methods: The p53 codon 72 polymorphism (rs1042522) was analyzed using allele-specific primer polymerase chain reaction. Proportions of genotypes and the proline (Pro-P) homozygote (Read more...)

Full Story →