Secondary Outcomes in a Clinical Trial of Carotenoids with Coantioxidants versus Placebo in Early Age-related Macular Degeneration
Purpose:
To report the secondary outcomes in the Carotenoids with Coantioxidants in Age-Related Maculopathy trial.
Design:
Randomized double-masked placebo-controlled clinical trial (registered as ISRCTN 94557601).
Participants:
Participants included 433 adults 55 years of age or older with early age-related macular degeneration (AMD) in 1 eye and late-stage disease in the fellow eye (group 1) or early AMD in both eyes (group 2).
Intervention:
An oral preparation containing lutein (L), zeaxanthin (Z), vitamin C, vitamin E, copper, and zinc or placebo. Best-corrected visual acuity (BCVA), contrast sensitivity (CS), Raman spectroscopy, stereoscopic (Read more...)