Effect of Corneal Collagen Cross-Linking on Corneal Innervation, Corneal Sensitivity, and Tear Function of Patients with Keratoconus
Purpose:
To evaluate the effect of corneal collagen cross-linking (CXL) on corneal innervation, corneal sensitivity, and tear function in patients with keratoconus.
Design:
Prospective, interventional case series.
Participants:
Twenty-four patients with bilateral keratoconus (30 eyes) who presented to the Institute of Vision and Optics, University of Crete, from May 2008 to October 2008.
Methods:
Patients underwent CXL. Confocal microscopic analysis of corneal sub-basal nerve plexus (total nerve length per image), corneal sensitivity (assessed with the Cochet–Bonnet esthesiometer), basic tear secretion (assessed with Schirmer's I test with anesthesia), and tear film (Read more...)