Scleral Necrosis after Plaque Radiotherapy of Uveal Melanoma: A Case-Control Study
Purpose:
To identify risk factors and outcome of scleral necrosis after plaque radiotherapy of uveal melanoma.
Design:
Case-control study.
Participants:
A total of 73 cases with scleral necrosis and 73 controls without necrosis after plaque radiotherapy. Controls were matched for anteroposterior tumor epicenter and follow-up duration.
Intervention:
Plaque radiotherapy with iodine-125, cobalt-60, iridium-192, or ruthenium-106.
Main Outcome Measures:
Scleral necrosis.
Results:
Of 5057 patients treated with plaque radiotherapy for uveal melanoma, 73 (1%) developed radiotherapy-induced scleral necrosis. Scleral necrosis occurred in <1% of patients (3/1140) when plaque radiotherapy was used (Read more...)