Fuchs’ Endothelial Corneal Dystrophy: Subjective Grading versus Objective Grading Based on the Central-to-Peripheral Thickness Ratio
Purpose:
To assess interobserver agreement between 2 corneal specialists grading Fuchs' dystrophy clinically and to determine if the corneal central-to-peripheral thickness ratio (CPTR) may be an alternative and objective metric of disease severity.
Design:
Cross-sectional study.
Participants:
Forty-five eyes (26 subjects) with mild and moderate Fuchs' dystrophy, 73 eyes (60 subjects) with advanced Fuchs' dystrophy, and 267 eyes (142 subjects) with normal corneas.
Methods:
Corneas with Fuchs' dystrophy were graded by 2 corneal specialists based on the confluence and area of guttae and the presence or absence of edema. Central (Read more...)