Application for Tacrolimus Ointment in Treating Refractory Inflammatory Ocular Surface Diseases – Corrected Proof
Purpose: To evaluate the therapeutic effects of topical tacrolimus ointment on refractory inflammatory ocular surface diseases.Design: Retrospective interventional consecutive case series.Methods: In Severance Hospital, Seoul, South Korea, 0.02% tacrolimus ointment was topically applied 1 to 3 times per day, depending on disease severity, for up to 31 months in eyes of 12 consecutive patients with refractory inflammatory ocular surface diseases who had previously been treated with steroid therapy. Seven patients had chronic cicatrizing conjunctivitis (6 cases caused by Stevens-Johnson syndrome and 1 attributable to ocular cicatricial pemphigoid); 4 had scleritis (3 necrotizing scleritis, 1 recurrent nodular scleritis); and 1 patient had (Read more...)