Epimacular Brachytherapy for Neovascular Age-Related Macular Degeneration (CABERNET) Fluorescein Angiography and Optical Coherence Tomography – Corrected Proof

Purpose: To report the fluorescein angiography (FA) and optical coherence tomography (OCT) results of a clinical trial of epimacular brachytherapy (EMBT) used for the treatment of neovascular age-related macular degeneration (AMD). Design: Pivotal multicenter, active-controlled, randomized clinical trial. Participants: A total of 494 participants with treatment-naïve, neovascular AMD. Methods: Participants with classic, minimally classic, and occult lesions were randomized to receive (a) EMBT and 2 mandated monthly ranibizumab injections followed by pro re nata (PRN) ranibizumab or (b) 3 mandated monthly ranibizumab injections followed by mandated quarterly plus PRN ranibizumab. Participants underwent FA at screening and at months 1, 6, (Read more...)

Full Story →