Penetration of a Topically Administered Anti–Tumor Necrosis Factor Alpha Antibody Fragment into the Anterior Chamber of the Human Eye – Corrected Proof
Objective:
To determine whether topically applied ESBA105, a single-chain antibody fragment against tumor necrosis factor (TNF)-α, could efficiently penetrate into the anterior chamber of the human eye.
Design:
Multicenter, interventional cohort study.
Participants:
Otherwise healthy patients undergoing cataract surgery (cohorts I–III) or combined cataract surgery and vitrectomy (cohort IV).
Methods:
ESBA105 (n = 57) or placebo (n = 22) was preoperatively applied as eye drops to 1 eye in patients scheduled for cataract surgery (n = 73) or combined cataract surgery and vitrectomy (n = 6). ESBA105 was administered on the day of surgery at 1-hour intervals (last dose 1 (Read more...)