Retinoblastoma not linked solely to <i>RB1</i> mutations, study finds

Some cases of retinoblastoma may occur due to amplification of the MYCN oncogene rather than mutation of both alleles of the RB1 retinoblastoma suppressor gene, a study found. In such nonhereditary cases, children may not be at heightened risk of retinoblastomas in the other eye, future cancers or further familial risk, the study authors wrote.

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