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We thank Sadun et al for their letter. We are in agreement that inappropriate testing leads not only to delays in final diagnosis and definitive treatment, but can result in further unnecessary testing and intervention. We would also amplify the point they raise regarding pretest probabilities. Pretest probability refers to the probability of the target disorder before a diagnostic test result is known. This can then be used to calculate likelihood ratios, which have advantages over sensitivity and specificity in that they are less likely to change with the prevalence (Read more...)

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