Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation – Corrected Proof

Purpose: To investigate whether modification of liver complement factor H (CFH) production, by alteration of liver CFH Y402H genotype through liver transplantation (LT), influences the development of age-related macular degeneration (AMD).Design: Multicenter, cross-sectional study.Participants: We recruited 223 Western European patients ≥55 years old who had undergone LT ≥5 years previously.Methods: We determined AMD status using a standard grading system. Recipient CFH Y402H genotype was obtained from DNA extracted from recipient blood samples. Donor CFH Y402H genotype was inferred from recipient plasma CFH Y402H protein allotype, measured using enzyme-linked immunosorbent assays. This approach was verified by genotyping donor tissue from a (Read more...)

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Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation – Corrected Proof

Purpose: To investigate whether modification of liver complement factor H (CFH) production, by alteration of liver CFH Y402H genotype through liver transplantation (LT), influences the development of age-related macular degeneration (AMD).Design: Multicenter, cross-sectional study.Participants: We recruited 223 Western European patients ≥55 years old who had undergone LT ≥5 years previously.Methods: We determined AMD status using a standard grading system. Recipient CFH Y402H genotype was obtained from DNA extracted from recipient blood samples. Donor CFH Y402H genotype was inferred from recipient plasma CFH Y402H protein allotype, measured using enzyme-linked immunosorbent assays. This approach was verified by genotyping donor tissue from a (Read more...)

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