Macular Hole Surgery in Patients with End-stage Choroideremia – Corrected Proof

Objective: To assess macular hole surgery in patients with end-stage choroideremia with regard to anatomic closure and visual outcome.Design: Retrospective, interventional case series.Participants: Thirty adult male patients with a diagnosis of advanced choroideremia were reviewed and underwent spectral domain optical coherence tomography (OCT) as part of the screening process for a gene therapy clinical trial. From within that cohort, 3 were identified as having a full-thickness macular hole (FTMH).Methods: A 23-gauge pars plana vitrectomy was performed with peeling of the inner limiting membrane and gas tamponade. Preoperative best-corrected visual acuity ranged from perception of light to 6/24.Main Outcome Measures: Prevalence (Read more...)

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