Why Does the Healthy Cornea Resist Pseudomonas aeruginosa Infection? – Corrected Proof
Purpose: To provide our perspective on why the cornea is resistant to infection based on our research results with Pseudomonas (P) aeruginosa. We focus on our current understanding of the interplay between bacteria, tear fluid, and the corneal epithelium that determines health as the usual outcome, and propose a theoretical model for how contact lens wear might change those interactions to enable susceptibility to P aeruginosa infection.Methods: Use of “null-infection” in vivo models, cultured human corneal epithelial cells, contact lens–wearing animal models, and bacterial genetics help to elucidate mechanisms by which P aeruginosa survives at the ocular surface, adheres, and traverses (Read more...)