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We thank Caimi and associates for their interest in our article regarding serous macular detachment in Waldenström macroglobulinemia. They describe 1 patient in whom cystoid macular edema and serous macular detachment was present without outer retinal disruption on spectral-domain optical coherence tomography. In our case series, 4 patients had bilateral cystoid macular edema overlying a serous retinal detachment. All 4 eyes of the 2 patients who underwent spectral-domain optical coherence tomography imaging demonstrated outer retinal defects overlying a serous macular detachment. We hypothesized that these defects could provide a pathway for immunoglobulin M molecules and intraretinal fluid to enter the (Read more...)