Chronic ocular hypertension may occur after repeated intravitreal anti-VEGF injections

PARIS — Repeated intravitreal anti-VEGF injections might cause chronic ocular hypertension in some patients, according to a study. "The exact mechanism is still unknown, but we may hypothesize a correlation with the repeated occurrence of transient acute IOP elevation that follows [intravitreal] injection. Alteration of the aqueous outflow may also be caused by the presence of silicone oil droplets or protein aggregates in the trabecular meshwork or by an autoimmune reaction leading to chronic trabeculitis," Emilie Agard, MD, said at the meeting of the French Society of Ophthalmology.

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