The Age-Related Maculopathy Susceptibility 2 Polymorphism and Polypoidal Choroidal Vasculopathy in Asian Populations: A Meta-Analysis – Corrected Proof

Objective: To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations.Methods: We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed.Main Outcome Measure: Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV.Results: The (Read more...)

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