Clinicopathologic and Immunohistochemical Studies of Conjunctival Large Cell Acanthoma, Epidermoid Dysplasia, and Squamous Papilloma – Corrected Proof

Purpose: To evaluate clinicopathologically and immunohistochemically a spectrum of conjunctival squamous proliferations.Design: Retrospective clinicopathologic study.Methods: One large cell acanthoma, 7 epidermoid dysplasias, and 4 squamous papillomas were evaluated with microscopy and biomarkers Ki-67, p53, epithelial membrane antigen (EMA), Ber-EP4, AE1, AE3, and 8 individual cytokeratins. Normal associated conjunctiva served as a baseline for interpretation.Results: The large cell acanthoma recurred 4 times but retained its benign histopathologic features. The cells were 2-3 times larger than the keratinocytes of the normal conjunctiva and did not display atypia. Immunohistochemistry revealed a low Ki-67 proliferation index (PI) in the large cell acanthoma compared with (Read more...)

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