Diagnostic Precision of Retinal Nerve Fiber Layer and Macular Thickness Asymmetry Parameters for Identifying Early Primary Open-Angle Glaucoma – Corrected Proof

Purpose: To evaluate the diagnostic capabilities of intereye and intraeye differences in retinal nerve fiber layer (RNFL) thickness and macular thickness for identifying early primary open-angle glaucoma (POAG).Design: Prospective, cross-sectional cohort study.Methods: All subjects were enrolled from an ongoing institutional glaucoma study. We used spectral-domain optical coherence tomography (Spectralis; Heidelberg Engineering) to obtain macular thickness (posterior pole asymmetry scan) and RNFL thickness (circumpapillary scan) in both eyes of 50 early POAG and 50 control subjects. Early POAG subjects had glaucomatous optic neuropathy with mild, reproducible visual field loss in at least 1 eye, and control subjects had normal intraocular pressures, (Read more...)

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