Gene Expression Profiling versus TNM Classification

We appreciate the opportunity to respond to the letter from Kivelä and Kujala regarding our recent article that prospectively evaluated a gene expression profile (GEP) prognostic test for uveal melanoma. One of us (J.W.H.) was a primary member of the committee that developed the current 7th edition American Joint Committee on Cancer TNM system for uveal melanoma; thus, we are quite knowledgeable of this system and how it is applied. We agree that the clinical TNM system stratifies patients with a particular cancer into multiple categories based on tumor size, (Read more...)

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