Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases

We read “Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases” by Poole Perry and associates. They report histopathology following enucleation in 4 cases. They accurately demonstrated that the lesions were composed of glial cells (mostly astrocytes) with scarcity of blood vessels. Their observations confirm other reports demonstrating that end-stage retinal vasoproliferative tumors following failed conservative treatments are composed predominantly of glial cells. They showed a fundus photograph of 1 case in which enucleation was performed 16 months after cryotherapy and many intravitreal injections of bevacizumab. We suspect that these treatments, designed to reduce tumor (Read more...)

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