Low-voltage X-ray therapy with anti-VEGF appears safe in treating neovascular AMD

One dose of low-voltage 16 Gy or 24 Gy X-ray irradiation in conjunction with as-needed ranibizumab injections appeared safe in patients with neovascular age-related macular degeneration at 12 months.The phase 1, open-label, nonrandomized, uncontrolled safety study included 47 eyes of 47 patients with neovascular AMD who received two 0.5-mg intravitreal injections of Lucentis (ranizumab, Genentech) at baseline and day 30 and one dose of 16 or 24 Gy X-ray therapy between days 1 and 14.

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