Intracameral Cyclosporine Drug Delivery System in High-risk Keratoplasty

We read with great interest the innovative work of Shi et al on cyclosporine intraocular drug delivery system for high-risk keratoplasty. It is not true that endothelial graft rejection often occurs within 2 weeks after transplantation, as authors stated. Many reports show similar data: Average interval between 8 and 10.5 months after graft. In fact, a recent study found that early rejections (within 6 months postoperatively) were almost 3 times less frequent than late rejections. In high-risk keratoplasty cases, the panorama is not very different, as in the clinical trial by (Read more...)

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