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Localized RNFL defects linked to retinal ganglion cell loss in glaucomatous eyes
Localized retinal nerve fiber layer defects were associated with high neuronal losses, according to a study.The study comprised patients who participated in the African Descent and Glaucoma Evaluation Study and the Diagnostic Innovations in Glaucoma Study; 198 normal eyes of 138 patients and 66 glaucomatous eyes of 55 patients were included.All patients underwent standard automated perimetry, spectral-domain optical coherence tomography and fundus stereophotography. A structure-function index was used to estimate retinal ganglion cell loss.