The Association between Cataract Surgery and Atypical Antipsychotic Use: A Nested Case-Control Study – Corrected Proof

Purpose: To investigate cataract risk associated with the use of atypical antipsychotics.Design: Retrospective, nested case-control study.Methods: A large health claims database (The British Columbia Ministry of Health Databases) from British Columbia, Canada, was used from January 2000 through December 2007. Cases were defined as clinically significant cataracts requiring surgery and were identified using cataract surgery procedure codes. For each case, 4 to 10 controls were selected randomly using a density-based sampling approach and were matched to cases by age and calendar time. Rate ratios were calculated for users of atypical and typical antipsychotics adjusting for known cataractogenic factors.Results: One hundred (Read more...)

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