We appreciate the thoughtful comments of Rath and associates and agree with their assessment of the limitations of our study. We intended to examine the diagnostic yield and therapeutic benefit of nonquantitative polymerase chain reaction (PCR) in the management of anterior uveitis. Our data suggest that under these conditions PCR has limited utility. We agree that quantitative PCR can have greater utility in select cases. We also wish to point out that complications, even severe ones, can occur. Given our data, we cannot advocate routine use of nonquantitative PCR for anterior uveitis.