The United Kingdom Glaucoma Treatment Study: A Multicenter, Randomized, Double-masked, Placebo-controlled Trial: Baseline Characteristics – Corrected Proof

Objective: The United Kingdom Glaucoma Treatment Study (UKGTS) tests the hypothesis that treatment with a topical prostaglandin analog, compared with placebo, reduces the frequency of visual field (VF) deterioration events in patients with open-angle glaucoma (OAG) by 50% over a 2-year period. Additional goals are to evaluate study power with novel clinical trial outcomes: (1) VF deterioration velocity and (2) VF and quantitative imaging measurements modeled as joint outcomes.Design: The UKGTS is a randomized, double-masked, placebo-controlled, multicenter treatment trial for OAG.Participants: A total of 516 patients with newly diagnosed (previously untreated) OAG were prospectively recruited at 10 UK centers between (Read more...)

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