Length of Day during Early Gestation as a Predictor of Risk for Severe Retinopathy of Prematurity – Corrected Proof

Purpose: Fetal mice require light exposure in utero during early gestation for normal vascular development in the eye. Because angiogenic abnormalities in retinopathy of prematurity (ROP) are manifested in preterm infants, we investigated whether day length during early gestation was associated with severe ROP (SROP).Design: Single-center, retrospective cohort study.Participants: We included a total of 343 premature infants (401–1250 g birth weight [BW], from 1998–2002): 684 eyes (1 eye each of 2 patients excluded) with 76 eyes developing SROP, defined as (1) classic threshold ROP in zone I or II, (2) type 1 ROP in zone I, or (3) in a (Read more...)

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