Follow-up in older adults shows a high rate of anisometropia, or differing levels of visual abnormalities between eyes, reports a study in Optometry and Vision Science, official journal of the American Academy of Optometry. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.
Month: November 2013
Macular dystrophies mimicking age-related macular degeneration
Publication date: Available online 28 November 2013 Source:Progress in Retinal and Eye Research Author(s): Nicole T.M. Saksens , Monika Fleckenstein , Steffen Schmitz-Valckenberg , Frank G. Holz , Anneke I. den Hollander , Jan E.E…
IRIS Registry Unveiled
The American Academy of Ophthalmology debuts the nation’s first eye disease registry, and it promises to revolutionize the practice of ophthalmology. Medscape Medical News
Ophthalmologists Confront Affordable Care Act Complications
New regulations are challenging ophthalmologists to be innovative and look for opportunities in a changing healthcare environment. Medscape Medical News
KKR to acquire minority stake in Gland Pharma for about $200 million
Gland Pharma Limited, a leading Indian pure-play generic injectable pharmaceutical products company, today announced an agreement under which KKR, a leading global investment firm, will acquire a minority stake in the Company for approximately US$200 m…
Cedars-Sinai researchers design new procedure to treat stem cell-related corneal blindness
Researchers in the Cedars-Sinai Regenerative Medicine Institute have designed and tested a novel, minute-long procedure to prepare human amniotic membrane for use as a scaffold for specialized stem cells that may be used to treat some corneal diseases.
Biologics Projected to Transform Uveitis Treatment
Biologic therapies hold promise and could be better able to spare steroids than older uveitis treatments. Medscape Medical News
Micro-Stent Safe With Cataract Surgery for Glaucoma
The CyPass Micro-Stent implanted at the same time as cataract surgery lowers intraocular pressure and cuts medication use in patients with glaucoma, 2-year results from CYCLE show. Medscape Medical News
Discriminant Value of Custom Ocular Response Analyzer Waveform Derivatives in Keratoconus – Corrected Proof
Purpose: To evaluate the performance of corneal hysteresis (CH), corneal resistance factor, and 16 investigator-derived Ocular Response Analyzer (ORA) variables in distinguishing keratoconus (KC) from the nondiseased state.Design: Retrospective case series.Participants: Fifty-four eyes of 27 unaffected patients and 49 eyes of 25 KC patients from the Instituto de Olhos, Rio de Janeiro, Brazil.Methods: Sixteen candidate variables were derived from exported ORA signals to characterize putative indicators of biomechanical behavior. Area under the receiver operating characteristic curve (AUC) and the Z statistic were used to compare diagnostic performance.Main Outcome Measures: Discriminant value of standard and derived ORA variables as measured by (Read more...)
En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy – Corrected Proof
Objective: To characterize en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced-depth swept-source optical coherence tomography (SS-OCT) prototype…
Cataract Surgery in Patients with Fuchs’ Endothelial Corneal Dystrophy: When to Consider a Triple Procedure – Corrected Proof
Purpose: To ascertain preoperative and intraoperative factors that predict the need for endothelial keratoplasty (EK) in patients with Fuchs’ endothelial corneal dystrophy (FECD) undergoing cataract surgery.Design: Prospective, observational cohort stu…
Systemic Complement Inhibition with Eculizumab for Geographic Atrophy in Age-Related Macular Degeneration: The COMPLETE Study – Corrected Proof
Purpose: To evaluate the effect of eculizumab, a systemic inhibitor of complement component (C5), on the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD).Design: Prospective, double-masked, randomized clinical t…
Predicting Progression of Glaucoma from Rates of Frequency Doubling Technology Perimetry Change – Corrected Proof
Purpose: To evaluate the ability of longitudinal frequency doubling technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects.Design: Prospective, observational cohort study.Participants: The study included 587 eyes of 367 patients with suspected glaucoma at baseline selected from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES). These eyes had an average of 6.7±1.9 FDT tests during a mean follow-up time of 73.1±28.0 months.Methods: Glaucoma suspects had intraocular pressure (IOP) >21 mmHg or an optic disc appearance suspicious of glaucoma. All patients had normal (Read more...)
Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Results of the OPUS-1 Phase 3 Study – Corrected Proof
Purpose: To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease.Design: Prospective, randomized, double-masked, placebo-controlled, parallel arm, multicenter clinical trial.Participants: A total of 588 adult subjects with dry eye disease.Methods: Eligible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (vehicle) twice daily for 84 days after a 14-day open-label placebo run-in period. After enrollment (day 0), subjects were evaluated at days 14, 42, and 84. Key objective (fluorescein and lissamine staining scores [Ora scales]) and subjective (Ocular Surface Disease Index [OSDI], 7-item visual analog scale, and ocular (Read more...)
Achieving Target Refraction after Cataract Surgery – Corrected Proof
Purpose: To evaluate the difference between target and actual refraction after phacoemulsification and intraocular lens implantation at an academic teaching institution’s Comprehensive Ophthalmology Service.Design: Retrospective study.Participants: We …
Femtosecond laser-assisted cataract surgery linked to increased prostaglandin levels
Femtosecond laser-assisted cataract surgery was associated with increased prostaglandin concentrations in the aqueous humor, according to a study. Four studies were conducted; 113 patients underwent femtosecond laser-assisted cataract surgery, and 107 patients underwent conventional phacoemulsification and served as controls. After femtosecond laser pretreatment and at the beginning of conventional surgery, the investigators collected aqueous humor samples. Total prostaglandin and prostaglandin E2 concentrations were measured with an enzyme-linked immunoassay.
VIDEO: Surgeon discusses femtosecond cataract advantages
John A. Hovanesian, MD, relates positive findings from femtosecond-laser assisted cataract surgery results at the American Academy of Ophthalmology meeting in New Orleans.
VIDEO: Surgeon discusses the latest on the glued IOL technique
Amar Agarwal, MS, FRCS, FRCOphth, discusses the latest techniques on glued IOL at the American Academy of Ophthalmology meeting in New Orleans.
Study shows most corneal transplants have remarkable longevity regardless of donor age
Ten years after a transplant, a cornea from a 71-year-old donor is likely to remain as healthy as a cornea from a donor half that age, and corneas from donors over 71 perform slightly less well but still remain healthy for most transplant recipients, a…
Risk for retinal detachment not increased with fluoroquinolones
Oral fluoroquinolone use did not lead to higher risk for retinal detachment, researchers from Statens Serum Institut in Copenhagen, Denmark, have found.“Given the limited power, this study can only rule out more than a threefold relative increase in the risk of retinal detachment associated with current fluoroquinolone use,” the researchers wrote in JAMA. “However, any differences in absolute risk are likely to have limited, if any, clinical significance.”