The Shields et al article describes an “ABCDEF guide” to aid diagnosis of iris nevus growth into melanoma. The authors note that iris melanomas are exceedingly rare, carry a low risk for transformation to melanoma, and in their analyses of 41 years' worth of data, only 2%, or 27, of the 1611 eyes with iris nevi developed melanoma. This sharply contrasts with cutaneous malignant melanoma (CMM), the fifth most common cancer in women and men, which will strike >75 000 new individuals this year, 150 000 if melanomas in situ are included. The (Read more...)

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