Corneal changes in Xeroderma Pigmentosum: a clinicopathological Report – Accepted Manuscript

Abstract: Purpose: To report the clinicopathological features of corneal involvement in patients with Xeroderma pigmentosum.Design: Retrospective review of corneal histopathology.Methods: Thirteen corneal specimens of 11 patients with Xeroderma pigmentosum who underwent keratoplasty (lamellar/full- thickness) for corneal involvement were studied. Five microns thick sections were made from all the samples and stained using Hematoxylin & Eosin (H & E) and Periodic Acid Schiff (PAS) stains. A light microscopic examination was performed to study the histopathological changes.Results: The corneal findings on clinical examination were haze, scarring, vascularization, stromal edema, pigment clumps on endothelial surface and corneal thinning. The histopathological evaluation revealed changes (Read more...)

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