Incidence of Pineal Gland Cyst and Pineoblastoma in Children With Retinoblastoma During the Chemoreduction Era

We carefully read the recent paper by Ramasubramanian and associates on the incidence of pineal gland cyst and pineoblastoma in retinoblastoma patients. Over a 12-year period this busy center saw only 4 pineoblastomas in 408 patients. Despite the small numbers of pineoblastomas and admitted absence of statistical significance, the authors concluded that “systemic chemotherapy…(may) possibly indicate a systemic protective effect.”

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