Common Variants in the Complement Factor H Gene Confer Genetic Susceptibility to Central Serous Chorioretinopathy – Corrected Proof

Purpose: To investigate whether complement factor H (CFH) gene DNA variants are associated with central serous chorioretinopathy (CSCR).Design: Cross-sectional study.Participants: A case-control group of 140 CSCR subjects and 2 different control groups: 934 population-based controls and 335 hospital-based controls.Methods: Five single-nucleotide polymorphisms (SNPs) in CFH (rs3753394, rs800292, rs2284664, rs1329428, and rs106548) were evaluated for association with CSCR in 2 separate association analyses comparing CSCR subjects with 2 different control groups. Genotyping was performed using TaqMan technology (Applied Biosystems, Foster City, CA).Main Outcome Measures: Allele and haplotype frequencies of the 5 variants in the CFH region.Results: Highly statistically significant associations with (Read more...)

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