This Issue At A Glance

Shah et al (p. 352) assessed the clinical features, treatment, and prognosis of patients with uveal metastasis from lung cancer. They found that 44% of patients with uveal metastasis had not been diagnosed with lung cancer at the time the metastasis was discovered. In addition, they found that, although current methods of ocular treatment allow patients to retain the globe and provide stable vision, long-term prognosis remains poor. For this retrospective review, the researchers analyzed the charts of 194 patients (229 eyes with 374 metastases). The main outcome measures were tumor control, visual acuity, and mortality. Tumor location included choroid (88%), ciliary body (2%), and iris (10%); bilateral involvement was noted in 18% of patients. Most metastases were treated with teletherapy (31%); other methods included chemotherapy (18%), brachytherapy (9%), or chemotherapy plus teletherapy or brachytherapy (14%). Treatment was effective in local control of the uveal metastasis in 78% of patients; however, 1-year mortality from the time of diagnosis of the metastasis was 54%.