Lacrimal Gland Pleomorphic Adenoma and Carcinoma ex Pleomorphic Adenoma: Genomic Profiles, Gene Fusions, and Clinical Characteristics – Corrected Proof
Purpose: To study genetic alterations in lacrimal gland pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (Ca-ex-PA) with focus on copy number changes and expression patterns of the translocation target genes PLAG1, HMGA2, and CRTC1-MAML2 in relation to clinical data.Design: Experimental study.Participants: A total of 36 tumors from 32 patients with lacrimal gland PA or Ca-ex-PA were included in the study.Methods: Genome wide, high-resolution array-based comparative genomic hybridization (arrayCGH) and immunohistochemistry were used to study the genomic profiles and expression patterns of the translocation targets PLAG1, HMGA2, and CRTC1-MAML2.Main Outcome Measures: Copy number alterations (gains/losses) and protein expression of PLAG1, (Read more...)