In Vitro Susceptibility of Filamentous Fungal Isolates From a Corneal Ulcer Clinical Trial
Purpose: To describe the minimum inhibitory concentration (MIC) of fungal isolates to natamycin and voriconazole, and to compare these MICs to previous ocular susceptibility studies.Design: Experimental laboratory study using isolates from a randomized clinical trial.Methods: The Mycotic Ulcer Treatment Trial I was a randomized, double-masked, multicenter trial comparing topical natamycin and voriconazole for fungal keratitis treatment. Susceptibility testing to natamycin and voriconazole were performed according to Clinical and Laboratory Standards Institute methods. The relationship between organism and MIC was assessed. A literature review was performed to compare results to previous ocular susceptibility studies.Results: Of the 323 patients enrolled in the (Read more...)