Squalamine eye drops reach therapeutic concentrations in choroid

MIAMI — Squalamine eye drops achieve trough concentrations in the choroid well in excess of its threshold level to inhibit angiogenesis, a speaker said here. “Squalamine has some very promising properties,” Lawrence J. Singerman, MD, FACS, FICS, said at the Angiogenesis, Exudation, and Degeneration 2014 meeting. “One is long retention time in the posterior ocular tissues. Another is high potency, and it has ability to inhibit multiple angiogenic growth factors.”