Acetazolamide in combination with a weight-reduction diet slightly improved vision in patients with idiopathic intracranial hypertension, according to a study. The Idiopathic Intracranial Hypertension Treatment Trial, a multicenter, randomized, double-masked study, included 161 women and four men with idiopathic intracranial hypertension and mild vision loss. Eighty-six patients received acetazolamide, and 79 patients received a placebo. Dosage was up to 4 g daily. All patients were on a low-sodium weight-reduction diet.