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Reduced susceptibility to natamycin linked to larger infiltrate, perforation risk
Researchers have found that decreased susceptibility to natamycin is associated with increased 3-month infiltrate or scar size and increased chances of perforation. The researchers enrolled 323 patients in a randomized, double-masked clinical trial to compare clinical outcomes of topical natamycin monotherapy with that of voriconazole monotherapy for the treatment of fungal keratitis. Associations between minimum inhibitory concentration (MIC) and clinical outcomes were assessed. The study’s primary outcome was best corrected visual acuity at 3 months.