Clinical findings and management of neurotrophic keratopathy

Neurotrophic keratopathy is a degenerative disease characterized by impaired corneal epithelium healing and absence of corneal sensitivity. Corneal sensory denervation makes the cornea vulnerable to occult injury and poor healing that triggers a nonhealing epithelial defect. Epithelial breakdown can lead to ulceration, infection, melting and perforation.Clinical causes