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OSN Europe: Possible consequences on organogenesis, neurodevelopment still a concern with use of anti-VEGFs in ROP
There may be a rationale for using anti-VEGFs in cases of severe retinopathy of prematurity to prevent neovascularization, but concerns exist about the possible detrimental effects of VEGF suppression on the organogenesis and neurodevelopment of preterm infants.A study published earlier this year in JAMA Ophthalmology showed that Avastin (bevacizumab, Genentech/Roche) remained in the systemic circulation for as long as 8 weeks after intravitreal injection and that VEGF expression was inhibited for that time. And the same authors showed in a 2-year retrospective study, unpublished but presented at the American Society (Read more...)