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Prospective trial compares treatments in matched DME eyes of poor anti-VEGF responders
FLORENCE, Italy — A small prospective trial comparing the effect of two drugs showed better results with a dexamethasone implant than monthly ranibizumab when the same patient with diabetic macular edema previously did not respond well to ranibizumab.Eleven patients were included. They were stable, chronic patients with well-controlled diabetes, equal diabetic retinopathy and macular edema in both eyes, and a symmetric history of consistent anti-VEGF treatment every 4 to 6 weeks with suboptimal success and persistent DME, Tarek Hassan, MD, said at the FLOREtina meeting.