Piezo-ejection micro-dosing of phenylephrine showed comparable results to traditional eyedropper administration in pupil dilation, as well as less systemic absorption, according to a study.
The phase 2, masked, nonrandomized, crossover study evaluated pupil dilation with topical phenylephrine in 12 eyes of 12 patients administered by a conventional 32-µL eyedropper (2.5% or 10% formulation) and in the second eye by an 8-µL electronic micro-dose ejection (10% formulation).
Pupil diameter was measured before dosing and 15, 30, 45, 50, 75, 120 and 180 minutes after dosing, while safety
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